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Article

Reading-frame restoration with an apolipoprotein B gene frameshift mutation.

Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1992

Linton M F, Pierotti V, Young S G

Abstract excerpt

We examined a mutant human apolipoprotein B (apoB) allele that causes hypobetalipoproteinemia and has a single cytosine deletion in exon 26. This frameshift mutation was associated with the synthesis of a truncated apoB protein of the predicted size; however, studies in human subjects and minigene expression studies in cultured cells indicated that the mutant allele also yielded a full-length apoB protein. The...

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Identifiers

PMID: 1454832
DOI: 10.1073/pnas.89.23.11431
PMCID: PMC50565

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