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Mitochondrial DNA Genomes Reveal Relaxed Purifying Selection During Human Population Expansion after the Last Glacial Maximum.

Molecular biology and evolution - 4 Sept 2024

Zheng Hong-Xiang, Yan Shi, Zhang Menghan, Gu Zhenglong, Wang Jiucun, Jin Li

Abstract excerpt

Modern humans have experienced explosive population growth in the past thousand years. We hypothesized that recent human populations have inhabited environments with relaxation of selective constraints, possibly due to the more abundant food supply after the Last Glacial Maximum. The ratio of nonsynonymous to synonymous mutations (N/S ratio) is a useful and common statistic for measuring selective constraints. In...

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Identifiers

PMID: 39162340
DOI: 10.1093/molbev/msae175
PMCID: PMC11373649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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