Article
Height in pre- and postmenopausal women is influenced by estrogen receptor alpha gene polymorphisms.
The Journal of clinical endocrinology and metabolism - 1 Jan 2004
Schuit Stephanie C E, van Meurs Joyce B J, Bergink Arjan P, van der Klift Marjolein, Fang Yue, Leusink Geraline, Hofman Albert, van Leeuwen Johannes P T M, Uitterlinden André G, Pols Huibert A P
Abstract excerpt
The estrogen receptor alpha gene (ESR1) is known to be involved in metabolic pathways influencing growth. We have performed two population-based association studies using three common polymorphisms within this candidate gene to determine whether these are associated with variation in adult stature. In 607 women, aged 55-80 yr, from the Rotterdam Study, the ESR1 PvuII-XbaI haplotype 1 (px) and the L allele of the...
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