Article
Association of estrogen receptor alpha gene polymorphisms with BMD and their affect on estradiol levels in pre- and postmenopausal women in south Indian population from Andhra Pradesh.
Clinica chimica acta; international journal of clinical chemistry - 2 Apr 2010
Jeedigunta Yasovanthi, Bhoomi Reddy Pulla Reddy, Kolla Venkata Karunakar, Munshi Anjana, Ananthapur Venkateshwari, Narasimulu G, Akka Jyothy
Abstract excerpt
BACKGROUND: Osteoporosis is a multifactorial disorder with a strong genetic component and ESR1 is suggested as a candidate gene for osteoporosis. Therefore the present study is aimed to investigate the role of ESR1 gene polymorphisms and its influence on estradiol levels and BMD in osteoporotic women of Indian ethnicity. METHODS: Four-hundred twenty-seven osteoporotic women and 460 age matched controls were...
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