Article
Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B.
Gastroenterology - 1 Jan 2004
Peters Marion G, Hann Hw H w, Martin Paul, Heathcote E Jenny, Buggisch P, Rubin R, Bourliere M, Kowdley K, Trepo C, Gray Df D f, Sullivan M, Kleber K, Ebrahimi R, Xiong S, Brosgart Carol L
Abstract excerpt
BACKGROUND AND AIMS: Adefovir dipivoxil possesses potent in vitro and in vivo antiviral activity in wild-type hepatitis B. This study assessed the safety and efficacy of adefovir dipivoxil alone and in combination with lamivudine compared with ongoing lamivudine therapy in patients with chronic hepatitis B with compensated liver disease and lamivudine-resistant hepatitis B virus (HBV). METHODS: Fifty-nine...
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