Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B.

doi:10.1056/NEJMoa0802878

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Article

Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B.

The New England journal of medicine - 4 Dec 2008

Marcellin Patrick, Heathcote E Jenny, Buti Maria, Gane Ed, de Man Robert A, Krastev Zahary, Germanidis George, Lee Sam S, Flisiak Robert, Kaita Kelly, Manns Michael, Kotzev Iskren, Tchernev Konstantin, Buggisch Peter, Weilert Frank, Kurdas Oya Ovung, Shiffman Mitchell L, Trinh Huy, Washington Mary Kay, Sorbel Jeff, Anderson Jane, Snow-Lampart Andrea, Mondou Elsa, Quinn Joe, Rousseau Franck

Abstract excerpt

BACKGROUND: Tenofovir disoproxil fumarate (DF) is a nucleotide analogue and a potent inhibitor of human immunodeficiency virus type 1 reverse transcriptase and hepatitis B virus (HBV) polymerase. METHODS: In two double-blind, phase 3 studies, we randomly assigned patients with hepatitis B e antigen (HBeAg)-negative or HBeAg-positive chronic HBV infection to receive tenofovir DF or adefovir dipivoxil (ratio, 2:1)...

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PMID: 19052126
DOI: 10.1056/NEJMoa0802878

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