Cloning of an Mx cDNA from Atlantic Halibut ( <i>Hippoglossus hippoglossus</i> ) and Characterization of Mx mRNA Expression in Response to Double-Stranded RNA or Infectious Pancreatic Necrosis Virus

Abstract excerpt

Mx proteins are GTPases that are specifically induced by type I interferons (IFN) in vertebrates. Some mammalian Mx proteins have antiviral activity against certain RNA viruses. A 2.3-kb full-length cDNA clone of an Atlantic halibut Mx gene was isolated from a liver cDNA library. The open reading frame (ORF) predicts a 622 amino acid protein of 71.2 kDa possessing a tripartite GTP binding motif, a dynamin...

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