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Article

Constitutive EGFR signaling confers a motile phenotype to neural stem cells.

Molecular and cellular neurosciences - 1 Dec 2003

Boockvar John A, Kapitonov Dmitri, Kapoor Gurpreet, Schouten Joost, Counelis George J, Bogler Oliver, Snyder Evan Y, McIntosh Tracy K, O'Rourke Donald M

Abstract excerpt

The epidermal growth factor receptor (EGFR) has been shown to play an important role in brain development, including stem and precursor cell survival, proliferation, differentiation, and migration. To further examine the temporal and spatial requirements of erbB signals in uncommitted neural stem cells (NSCs), we expressed the ligand-independent EGF receptor, EGFRvIII, in C17.2 NSCs. These NSCs are known to...

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Source

Identifiers

PMID: 14697673
DOI: 10.1016/j.mcn.2003.09.011

Genes

EGFR
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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