Article
Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis.
The Journal of biological chemistry - 22 Oct 2004
Gande Roland, Gibson Kevin J C, Brown Alistair K, Krumbach Karin, Dover Lynn G, Sahm Hermann, Shioyama Susumu, Oikawa Tadao, Besra Gurdyal S, Eggeling Lothar
Abstract excerpt
The Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis possess several unique and structurally diverse lipids, including the genus-specific mycolic acids. Although the function of a number of genes involved in fatty acid and mycolic acid biosynthesis is known, information relevant to the initial steps within these biosynthetic pathways is relatively sparse. Interestingly, the...
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