Article
Significance of beta2-adrenergic receptor gene polymorphism in obesity and type 2 diabetes mellitus in Korean subjects.
Metabolism: clinical and experimental - 1 Jul 2002
Kim Sung-Hoon, Kim Dong-Jun, Seo In Ah, Min Yong-Ki, Lee Myung-Shik, Kim Kwang-Won, Lee Moon-Kyu
Abstract excerpt
Catecholamines play a central role in the regulation of energy expenditure, in part stimulating lipid mobilization through lipolysis in fat cells. The beta(2)-adrenergic receptor (ADRB2) is a major lipolytic receptor in human fat cells, and a recent study has shown that common polymorphisms occurring in codons 16 and 27 of the ADRB2 gene are significantly associated with obesity and lipolytic ADRB2 function in...
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