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Article

Distinct mechanisms determine transposon inheritance and methylation via small interfering RNA and histone modification.

PLoS biology - 1 Dec 2003

Lippman Zachary, May Bruce, Yordan Cristy, Singer Tatjana, Martienssen Rob

Abstract excerpt

Heritable, but reversible, changes in transposable element activity were first observed in maize by Barbara McClintock in the 1950s. More recently, transposon silencing has been associated with DNA methylation, histone H3 lysine-9 methylation (H3mK9), and RNA interference (RNAi). Using a genetic approach, we have investigated the role of these modifications in the epigenetic regulation and inheritance of six...

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PMID: 14691539
DOI: 10.1371/journal.pbio.0000067
PMCID: PMC300680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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