Article
Mutations in the SRY, DAX1, SF1 and WNT4 genes in Brazilian sex-reversed patients.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Jan 2004
Domenice S, Corrêa R V, Costa E M F, Nishi M Y, Vilain E, Arnhold I J P, Mendonca B B
Abstract excerpt
In most mammals, male development is triggered by the transient expression of the SRY gene, which initiates a cascade of gene interactions ultimately leading to the formation of a testis from the indifferent fetal gonad. Mutation studies have identified several genes essential for early gonadal development. We report here a molecular study of the SRY, DAX1, SF1 and WNT4 genes, mainly involved in sexual...
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