Article
A functional polymorphism in the SULT1A1 gene (G638A) is associated with risk of lung cancer in relation to tobacco smoking.
Carcinogenesis - 1 May 2004
Liang Gang, Miao Xiaoping, Zhou Yifeng, Tan Wen, Lin Dongxin
Abstract excerpt
Sulfotransferase 1A1, an important member of sulfotransferase superfamily, is involved in the biotransformation of many compounds including tobacco carcinogens. A single nucleotide polymorphism (G638A) in the sulfotransferase 1A1 (SULT1A1) gene causes Arg213His amino acid change and consequently results in significantly reduced enzyme activity and thermostability. We thus hypothesized that the variant SULT1A1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.