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Expression, purification, and characterization of His20 mutants of rat mevalonate kinase.

Protein expression and purification - 1 Nov 2003

Chu Xiusheng, Li Ding

Abstract excerpt

Mevalonate kinase plays a key role in regulating the biosynthesis of cholesterol in animal cells. Human mevalonate kinase His20Pro has been reported as one of the three common mutations in the mevalonate kinase gene in mevalonic aciduria and hyperimmunoglobulinemia D/periodic fever syndrome patients. His20 is also a highly conserved residue among all aligned mevalonate kinase sequences. To study the role of His20...

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PMID: 14680942
DOI: 10.1016/S1046-5928(03)00221-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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