Article
Biochemical and X-ray crystallographic studies on shikimate kinase: the important structural role of the P-loop lysine.
Protein science : a publication of the Protein Society - 1 Jun 2001
Krell T, Maclean J, Boam D J, Cooper A, Resmini M, Brocklehurst K, Kelly S M, Price N C, Lapthorn A J, Coggins J R
Abstract excerpt
Shikimate kinase, despite low sequence identity, has been shown to be structurally a member of the nucleoside monophosphate (NMP) kinase family, which includes adenylate kinase. In this paper we have explored the roles of residues in the P-loop of shikimate kinase, which forms the binding site for nucleotides and is one of the most conserved structural features in proteins. In common with many members of the...
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