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Article

Polymorphism of the cyclin D1 gene, CCND1, and risk for incident sporadic colorectal adenomas.

Cancer research - 1 Dec 2003

Lewis Ryan C, Bostick Roberd M, Xie Dawen, Deng Zonglin, Wargovich Michael J, Fina Michael F, Roufail Walter M, Geisinger Kim R

Abstract excerpt

Cyclin D1, encoded by the CCND1 gene and activated by the adenomatous polyposis coli-beta-catenin-T-cell factor/lymphoid enhancing factor pathway, induces G(1) to S-phase cell cycle transition, promoting cell proliferation. A recently described codon 242, exon 4, G to A single nucleotide polymorphism (A870G) produces a longer half-life cyclin D1. To investigate whether CCND1 genotype influences risk for...

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Source

Identifiers

PMID: 14679024

Genes

CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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