Article
Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors.
The pharmacogenomics journal - 1 Jan 2004
Wadelius M, Sörlin K, Wallerman O, Karlsson J, Yue Q-Y, Magnusson P K E, Wadelius C, Melhus H
Abstract excerpt
The required dose of the oral anticoagulant warfarin varies greatly, and overdosing often leads to bleeding. Warfarin is metabolised by cytochrome P450 enzymes CYP2C9, CYP1A2 and CYP3A. The target cell level of warfarin may be dependent on the efflux pump P-glycoprotein, encoded by the adenosine triphosphate-binding cassette gene ABCB1 (multidrug resistance gene 1). Genetic variability in CYP2C9, CYP3A5 and ABCB1...
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