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Article

Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2004

Hanai Shuji, Kanai Masayuki, Ohashi Sayaka, Okamoto Keiji, Yamada Mitsunori, Takahashi Hitoshi, Miwa Masanao

Abstract excerpt

Poly(ADP-ribosyl)ation has been suggested to be involved in regulation of DNA repair, transcription, centrosome duplication, and chromosome stability. However, the regulation of degradation of poly(ADP-ribose) and its significance are not well understood. Here we report a loss-of-function mutant Drosophila with regard to poly(ADP-ribose) glycohydrolase, a major hydrolyzing enzyme of poly(ADP-ribose). The mutant...

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Identifiers

PMID: 14676324
DOI: 10.1073/pnas.2237114100
PMCID: PMC314142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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