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Article

Mutation screening of the ALS2 gene in sporadic and familial amyotrophic lateral sclerosis.

Archives of neurology - 1 Dec 2003

Hand Collette K, Devon Rebecca S, Gros-Louis Francois, Rochefort Daniel, Khoris Jawad, Meininger Vincent, Bouchard Jean-Pierre, Camu William, Hayden Michael R, Rouleau Guy A

Abstract excerpt

BACKGROUND: Mutations in the ALS2 gene cause juvenile-onset autosomal recessive amyotrophic lateral sclerosis (ALS) and hereditary spastic paraplegia. OBJECTIVE: To assess the role of ALS2 among more common forms of ALS. METHODS: DNA from 95 unrelated familial, 95 unrelated sporadic, and 11 early-onset ALS patients was screened for mutations in ALS2 by denaturing high-performance liquid chromatography and direct...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14676054
DOI: 10.1001/archneur.60.12.1768

Genes

ALS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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