Article
SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis.
Archives of neurology - 1 Nov 2011
Fecto Faisal, Yan Jianhua, Vemula S Pavan, Liu Erdong, Yang Yi, Chen Wenjie, Zheng Jian Guo, Shi Yong, Siddique Nailah, Arrat Hasan, Donkervoort Sandra, Ajroud-Driss Senda, Sufit Robert L, Heller Scott L, Deng Han-Xiang, Siddique Teepu
Abstract excerpt
BACKGROUND: The SQSTM1 gene encodes p62, a major pathologic protein involved in neurodegeneration. OBJECTIVE: To examine whether SQSTM1 mutations contribute to familial and sporadic amyotrophic lateral sclerosis (ALS). DESIGN: Case-control study. SETTING: Academic research. Patients A cohort of 546 patients with familial (n = 340) or sporadic (n = 206) ALS seen at a major academic referral center were screened...
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