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Article

UBQLN2 mutations are rare in French and French-Canadian amyotrophic lateral sclerosis.

Neurobiology of aging - 1 Sept 2012

Daoud Hussein, Suhail Hamid, Szuto Anna, Camu William, Salachas Francois, Meininger Vincent, Bouchard Jean-Pierre, Dupré Nicolas, Dion Patrick A, Rouleau Guy A

Abstract excerpt

Mutations in the UBQLN2 gene, which encodes a member of the ubiquitin-like protein family (ubiquilin-2), have been recently identified in patients with dominant X-linked amyotrophic lateral sclerosis (ALS) and ALS with dementia. We report here the sequencing of the UBQLN2 gene in 590 ALS patients of French and French-Canadian ancestry. We identified two novel missense mutations (p.S155N and p.P189T) in two...

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Identifiers

PMID: 22560112
DOI: 10.1016/j.neurobiolaging.2012.03.015

Genes

UBQLN2

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