Article
[Types and emergence time of YMDD motif mutation in hepatitis B virus polymerase gene during lamivudine treatment].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology - 1 May 2003
Liang Wei-feng, Yang Dan-hong, Shen Yue-hong, Xie Yuan-jun, Zhao Nian-feng
Abstract excerpt
OBJECTIVE: To study the types and emergence time of YMDD motif mutation in hepatitis B virus (HBV) polymerase gene during lamivudine treatment. METHODS: The serum samples were collected from 33 patients with HBV DNA rebounding and 2 non-responders after at least one year lamivudine treatment. HBV polymerase gene was amplificated by PCR, then the products were detected by restriction fragment length polymorphism...
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