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Article

Calcium-dependent regulation of tumour necrosis factor-alpha receptor signalling by copine.

The Biochemical journal - 15 Mar 2004

Tomsig Jose Luis, Sohma Hitoshi, Creutz Carl E

Abstract excerpt

The role of copines in regulating signalling from the TNF-alpha (tumour necrosis factor-alpha) receptor was probed by the expression of a copine dominant-negative construct in HEK293 (human embryonic kidney 293) cells. The construct was found to reduce activation of the transcription factor NF-kappaB (nuclear factor-kappaB) by TNF-alpha. The introduction of calcium into HEK293 cells either through the activation...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 14674885
DOI: 10.1042/BJ20031654
PMCID: PMC1224034

Genes

TNF
NEDD8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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