Article
Genetic toxicity of methamphetamine in vitro and in human abusers.
Environmental and molecular mutagenesis - 1 Jan 2003
Li Jih-Heng, Hu Heng-Cheng, Chen Wei-Bang, Lin Shih-Ku
Abstract excerpt
Methamphetamine (METH) is a widely abused psychomotor stimulant. Although numerous studies have examined METH-induced neurotoxicity, its ability to produce genotoxic effects has not been evaluated. In this article, we report on the genotoxicity of METH in vitro and in human METH abusers. METH induced his(+) revertants in Salmonella typhimurium strains TA98 and TA100, and increased the frequency of hprt mutants,...
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