Article
Ex vivo characterization of tumor-derived melanoma antigen encoding gene-specific CD8+cells in patients with hepatocellular carcinoma.
Journal of hepatology - 1 Jan 2004
Zerbini Alessandro, Pilli Massimo, Soliani Paolo, Ziegler Stefanie, Pelosi Guido, Orlandini Alessandra, Cavallo Cristina, Uggeri Jacopo, Scandroglio Renato, Crafa Pellegrino, Spagnoli Giulio C, Ferrari Carlo, Missale Gabriele
Abstract excerpt
BACKGROUND/AIMS: Members of the melanoma antigen encoding gene family are expressed in tumors of different histological types but not in normal tissue. For this reason, they are attractive targets for cancer immunotherapy. METHODS: In the present study, we analyzed the expression of MAGE-1 and -3 genes in the hepatocellular carcinoma (HCC) tissue as well as frequency, phenotype and function of circulating and...
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