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Article

Patterns of evolutionary constraints on genes in humans.

BMC evolutionary biology - 7 Oct 2008

De Subhajyoti, Lopez-Bigas Nuria, Teichmann Sarah A

Abstract excerpt

BACKGROUND: Different regions in a genome evolve at different rates depending on structural and functional constraints. Some genomic regions are highly conserved during metazoan evolution, while other regions may evolve rapidly, either in all species or in a lineage-specific manner. A strong or even moderate change in constraints in functional regions, for example in coding regions, can have significant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18840274
DOI: 10.1186/1471-2148-8-275
PMCID: PMC2587479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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