Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Herpes simplex virus type 1 immediate-early gene expression is required for the induction of apoptosis in human epithelial HEp-2 cells.

Journal of virology - 1 Jan 2004

Sanfilippo Christine M, Chirimuuta Fungai N W, Blaho John A

Abstract excerpt

Wild-type herpes simplex virus type 1 (HSV-1) induces apoptosis in human epithelial HEp-2 cells, but infected cell proteins produced later in infection block the process from killing the cells. Thus, HSV-1 infection in the presence of the translational inhibitor cycloheximide (CHX) results in apoptosis. Our specific goal was to gain insight as to the viral feature(s) responsible for triggering apoptosis during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to Cycloheximide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dactinomycin

Share to Genes, Immediate-Early

Share to Herpesvirus 1, Human

Share to Immediate-Early Proteins

Share to Ultraviolet Rays

Share to Vero Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 14671104
DOI: 10.1128/jvi.78.1.224-239.2004
PMCID: PMC303390

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Herpes simplex virus type 1 immediate-early gene expression is required for the induction of apoptosis in human epithelial HEp-2 cells.PMID 14671104Read ↗

The Herpes Simplex Virus Type 1 Regulatory Protein ICP27 Is Required for the Prevention of Apoptosis in Infected Human CellsSemantic proximity Read ↗

Accumulation of herpes simplex virus type 1 early and leaky-late proteins correlates with apoptosis prevention in infected human HEp-2 cells.Semantic proximity Read ↗

ICP0 Gene Expression Is a Herpes Simplex Virus Type 1 Apoptotic TriggerSemantic proximity Read ↗

The herpes simplex virus major regulatory protein ICP4 blocks apoptosis induced by the virus or by hyperthermia.Semantic proximity Read ↗

Induction of apoptosis by herpes simplex virus type 1.Semantic proximity Read ↗

Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent mannerSemantic proximity Read ↗

Activation of Human Herpesvirus Replication by ApoptosisSemantic proximity Read ↗

Activation of NF-kappaB in cells productively infected with HSV-1 depends on activated protein kinase R and plays no apparent role in blocking apoptosis.Semantic proximity Read ↗

Repression of gene expression upon infection of cells with herpes simplex virus type 1 mutants impaired for immediate-early protein synthesisSemantic proximity Read ↗

Human cytomegalovirus IE1 and IE2 proteins block apoptosisSemantic proximity Read ↗

Viral mitochondria-localized inhibitor of apoptosis (UL37 exon 1 protein) does not protect human neural precursor cells from human cytomegalovirus-induced cell death.Semantic proximity Read ↗

Varicella-Zoster Virus ORF63 Inhibits Apoptosis of Primary Human NeuronsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.