Article
Viral mitochondria-localized inhibitor of apoptosis (UL37 exon 1 protein) does not protect human neural precursor cells from human cytomegalovirus-induced cell death.
The Journal of general virology - 1 Nov 2012
Hildreth Richard L, Bullough Matthew D, Zhang Aiping, Chen Hui-Ling, Schwartz Philip H, Panchision David M, Colberg-Poley Anamaris M
Abstract excerpt
Congenital human cytomegalovirus (HCMV) infection can cause severe brain abnormalities. Apoptotic HCMV-infected brain cells have been detected in a congenitally infected infant. In biologically relevant human neural precursor cells (hNPCs), cultured in physiological oxygen tensions, HCMV infection (m.o.i. of 1 or 3) induced cell death within 3 days post-infection (p.i.) and increased thereafter. Surprisingly, its...
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