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Varicella-Zoster Virus ORF63 Inhibits Apoptosis of Primary Human Neurons

26 Dec 2005

Abstract excerpt

Virus-encoded modulation of apoptosis may serve as a mechanism to enhance cell survival and virus persistence. The impact of productive varicella-zoster virus (VZV) infection on apoptosis appears to be cell type specific, as infected human sensory neurons are resistant to apoptosis, yet human fibroblasts readily become apoptotic. We sought to identify the viral gene product(s) responsible for this antiapoptotic...

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PMID: 16379003
DOI: 10.1128/jvi.80.2.1025-1031.2006

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