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Article

Reconstitution of caspase-8 sensitizes JB6 cells to TRAIL.

Biochemical and biophysical research communications - 22 Oct 2000

Kim I K, Chung C W, Woo H N, Hong G S, Nagata S, Jung Y K

Abstract excerpt

TRAIL induces apoptosis in various tumor cells. We report here that caspase-8 is required in TRAIL-induced cell death. Western blot analyses and enzyme assays showed that exposing Jurkat cells to TRAIL resulted in activation of caspases-8 followed by caspase-3 and -9. Acetyl-IETD-fluoromethylketone, a caspase-8 inhibitor, potently suppressed TRAIL-induced cell death compared to acetyl-DEVD-fluoromethylketone and...

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Identifiers

PMID: 11032723
DOI: 10.1006/bbrc.2000.3673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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