Article
Human serum haptoglobin is toxic to Plasmodium falciparum in vitro.
Molecular and biochemical parasitology - 1 Jan 2004
Imrie Heather, Ferguson David J P, Day Karen P
Abstract excerpt
Innate immune responses are important in the control of malaria, particularly in those who have not yet mounted an effective adaptive response. Here we report that the human serum acute phase protein, haptoglobin, is toxic to Plasmodium falciparum cultured in vitro. This effect is phenotype dependent and occurs during the trophozoite phase of the asexual life cycle. We propose that the increased levels of...
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