Article
Haptoglobin phenotype appears to affect the pathogenesis of American trypanosomiasis.
Annals of tropical medicine and parasitology - 1 Apr 2006
Calderoni D R, Andrade T Dos Santos, Grotto H Z W
Abstract excerpt
In Latin America, 16 million-18 million people are thought to be infected with Trypanosoma cruzi, the parasite that causes American trypanosomiasis. The pathophysiology of this disease, particularly that of its chronic phase, has yet to be fully elucidated. The major function of haptoglobin, an acute-phase plasma protein found in three different phenotypes (Hp1-1, Hp2-1 and Hp2-2), is to bind to free haemoglobin...
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