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Article

The HCMV gene products US11 and US2 differ in their ability to attack allelic forms of murine major histocompatibility complex (MHC) class I heavy chains.

The Journal of experimental medicine - 20 Jan 1997

Machold R P, Wiertz E J, Jones T R, Ploegh H L

Abstract excerpt

Human cytomegalovirus downregulates the expression of human class I major histocompatibility complex (MHC) molecules by accelerating destruction of newly synthesized class I heavy chains. The HCMV genome contains at least two genes, US11 and US2, each of which encode a product sufficient for causing the dislocation of newly synthesized class I heavy chains from the lumen of the endoplasmic reticulum to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9016885
DOI: 10.1084/jem.185.2.363
PMCID: PMC2211711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The HCMV gene products US11 and US2 differ in their ability to attack allelic forms of murine major histocompatibility complex (MHC) class I heavy chains.PMID 9016885Read ↗

Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation.Semantic proximity Read ↗

Binding of human cytomegalovirus US2 to major histocompatibility complex class I and II proteins is not sufficient for their degradation.Semantic proximity Read ↗

Subtle sequence variation among MHC class I locus products greatly influences sensitivity to HCMV US2- and US11-mediated degradation.Semantic proximity Read ↗

Human cytomegalovirus US2 destabilizes major histocompatibility complex class I heavy chainsSemantic proximity Read ↗

The Human Cytomegalovirus US10 Gene Product Delays Trafficking of Major Histocompatibility Complex Class I MoleculesSemantic proximity Read ↗

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the CytosolSemantic proximity Read ↗

Human Cytomegalovirus US2 Endoplasmic Reticulum-Lumenal Domain Dictates Association with Major Histocompatibility Complex Class I in a Locus-Specific MannerSemantic proximity Read ↗

Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2Semantic proximity Read ↗

Amino acid composition of α1/α2 domains and cytoplasmic tail of MHC class I molecules determine their susceptibility to human cytomegalovirus US11‐mediated down‐regulationSemantic proximity Read ↗

Rhesus Cytomegalovirus Contains Functional Homologues of US2, US3, US6, and US11Semantic proximity Read ↗

Dislocation of a type I membrane protein requires interactions between membrane-spanning segments within the lipid bilayer.Semantic proximity Read ↗

The MHC Class I Homolog of Human Cytomegalovirus Is Resistant to Down-Regulation Mediated by the Unique Short Region Protein (US)2, US3, US6, and US11 Gene ProductsSemantic proximity Read ↗

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