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Article

Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design

3 Dec 2003

Abstract excerpt

The causative agent of severe acute respiratory syndrome (SARS) is a previously unidentified coronavirus, SARS-CoV. The RNA-dependent RNA polymerase (RdRp) of SARS-CoV plays a pivotal role in viral replication and is a potential target for anti-SARS therapy. There is a lack of structural or biochemical data on any coronavirus polymerase. To provide insights into the structure and function of SARS-CoV RdRp, we...

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PMID: 14654687
DOI: 10.1093/nar/gkg916

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