Article
Mechanism and fitness costs of PR-39 resistance in Salmonella enterica serovar Typhimurium LT2.
Antimicrobial agents and chemotherapy - 1 Aug 2008
Pränting Maria, Negrea Aurel, Rhen Mikael, Andersson Dan I
Abstract excerpt
PR-39 is a porcine antimicrobial peptide that kills bacteria with a mechanism that does not involve cell lysis. Here, we demonstrate that Salmonella enterica serovar Typhimurium can rapidly acquire mutations that reduce susceptibility to PR-39. Resistant mutants appeared at a rate of 0.4 x 10(-6) per cell per generation. These mutants were about four times more resistant than the wild type and showed a greatly...
Topics
- Animals
- Anti-Bacterial Agents
- Antimicrobial Cationic Peptides
- Bacterial Proteins
- Drug Resistance, Multiple, Bacterial
- Female
- Genetic Complementation Test
- Mice
- Mice, Inbred BALB C
- Microbial Sensitivity Tests
- Models, Genetic
- Mutagenesis, Insertional
- Mutation
- Salmonella Infections, Animal