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Article

Mechanism and fitness costs of PR-39 resistance in Salmonella enterica serovar Typhimurium LT2.

Antimicrobial agents and chemotherapy - 1 Aug 2008

Pränting Maria, Negrea Aurel, Rhen Mikael, Andersson Dan I

Abstract excerpt

PR-39 is a porcine antimicrobial peptide that kills bacteria with a mechanism that does not involve cell lysis. Here, we demonstrate that Salmonella enterica serovar Typhimurium can rapidly acquire mutations that reduce susceptibility to PR-39. Resistant mutants appeared at a rate of 0.4 x 10(-6) per cell per generation. These mutants were about four times more resistant than the wild type and showed a greatly...

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Source

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Identifiers

PMID: 18519732
DOI: 10.1128/AAC.00205-08
PMCID: PMC2493140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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