Article
A different molecular pattern of beta-thalassemia mutations in northeast Brazil.
Hemoglobin - 1 Nov 2003
Araújo Aderson S, Silva l Wilson A Júnior, Leão Silvana A C, Bandeira Flavia C G M, Petrou Mary, Modell Bernadette, Zago Marco A
Abstract excerpt
The main hereditary hemoglobin (Hb) disorders of clinical significance in Brazil are sickle cell disease and beta-thalassemia (thal). The sickle gene was introduced by the slave trade, whereas beta-thal was introduced later, due to a massive immigration (mostly by Italians) between 1870 and 1953, mainly to the southeast region of Brazil. Molecular studies performed in the southeast of the country showed a marked...
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