Article
Α-Thalassemia: Genotypic Profile Associated with Ethnicity and Hematological Differentiation of Iron Deficiency Anemia in the Region of Uberaba, Minas Gerais, Brazil.
Hemoglobin - 1 Jan 2015
de Souza Renata A Volpe, Carlos Aline Menezes, de Souza Bruna M Bereta, Rodrigues Cibele Velloso, Pereira Gilberto de Araujo, Moraes-Souza Helio
Abstract excerpt
α-Thalassemia (α-thal) is a hereditary hemoglobinopathy characterized by microcytic anemia due to impaired production of α chains of human globin. Brazilian studies show that the most common genotype is an -α(3.7) deletion with the loss of one or two α genes. As the production of α chains is not as accentuated in these cases, the correct diagnosis can only be achieved through molecular analysis that is not...
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