Article
A highly effective and stable bispecific diabody for cancer immunotherapy: cure of xenografted tumors by bispecific diabody and T-LAK cells.
Cancer immunology, immunotherapy : CII - 1 Jun 2004
Hayashi Hiroki, Asano Ryutaro, Tsumoto Kouhei, Katayose Yu, Suzuki Masanori, Unno Michiaki, Kodama Hideaki, Takemura Shin-ichi, Yoshida Hiroshi, Makabe Koki, Imai Kohzoh, Matsuno Seiki, Kumagai Izumi, Kudo Toshio
Abstract excerpt
PURPOSE: In the field of cancer immunotherapy research, the targeting of effector cells with specific antibodies is a very promising approach. Recent advances in genetic engineering have made it possible to prepare immunoglobulin fragments consisting of variable domains using bacterial expression...
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