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Article

A highly effective and stable bispecific diabody for cancer immunotherapy: cure of xenografted tumors by bispecific diabody and T-LAK cells.

Cancer immunology, immunotherapy : CII - 1 Jun 2004

Hayashi Hiroki, Asano Ryutaro, Tsumoto Kouhei, Katayose Yu, Suzuki Masanori, Unno Michiaki, Kodama Hideaki, Takemura Shin-ichi, Yoshida Hiroshi, Makabe Koki, Imai Kohzoh, Matsuno Seiki, Kumagai Izumi, Kudo Toshio

Abstract excerpt

PURPOSE: In the field of cancer immunotherapy research, the targeting of effector cells with specific antibodies is a very promising approach. Recent advances in genetic engineering have made it possible to prepare immunoglobulin fragments consisting of variable domains using bacterial expression systems. METHODS: We have produced an anti-epidermal growth-factor receptor (EGFR) x anti-CD3 bispecific diabody (Ex3...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 14648071
DOI: 10.1007/s00262-003-0465-9
PMCID: PMC11032808

Genes

EGFR
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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