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Functional comparison of single-chain and two-chain anti-CD3-based bispecific antibodies in gene immunotherapy applications

1 May 2014

Abstract excerpt

Gene therapy to achieve in vivo secretion of recombinant anti-CD3 x anti-tumor bispecific antibodies in cancer patients is being explored as a strategy to counterbalance rapid renal elimination, thereby sustaining levels of bispecific antibodies in the therapeutic range. Here, we performed a comparative analysis between single- and two-chain configurations for anti-CD3 x anti-CEA (carcinoembryonic antigen)...

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Identifiers

PMID: 25057445
DOI: 10.4161/onci.28810

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