Alloimmunization to platelet antigen HPA-1a (PIA1) is strongly associated with both HLA-DRB3*0101 and HLA-DQB1*0201.

doi:10.1016/0198-8859(92)90036-m

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Article

Alloimmunization to platelet antigen HPA-1a (PIA1) is strongly associated with both HLA-DRB30101 and HLA-DQB10201.

Human immunology - 1 Jun 1992

L'Abbé D, Tremblay L, Filion M, Busque L, Goldman M, Décary F, Chartrand P

Abstract excerpt

Antibodies to the platelet HPA-1a antigen can elicit in the newborn a condition known as neonatal alloimmune thrombocytopenic purpura (NAITP). Previous studies based on RFLP analysis showed that 100% of HPA-1a-negative women who produced anti-HPA-1a antibodies (responders) were HLA-DRw52a (DRB3*0...

Topics

Alleles
Antigens, Human Platelet
Base Sequence
Female
Gene Frequency
Genes, MHC Class II
Genetic Predisposition to Disease
HLA-DQ Antigens
HLA-DQ beta-Chains
HLA-DR Antigens
HLA-DRB3 Chains
Humans
Immunity, Maternally-Acquired
Immunization
Incidence
Infant, Newborn
Isoantibodies
Maternal-Fetal Exchange

Source

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Identifiers

PMID: 1358865
DOI: 10.1016/0198-8859(92)90036-m

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1358865-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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