Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor.

doi:10.1200/JCO.2003.04.190

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Article

Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Dec 2003

Heinrich Michael C, Corless Christopher L, Demetri George D, Blanke Charles D, von Mehren Margaret, Joensuu Heikki, McGreevey Laura S, Chen Chang-Jie, Van den Abbeele Annick D, Druker Brian J, Kiese Beate, Eisenberg Burton, Roberts Peter J, Singer Samuel, Fletcher Christopher D M, Silberman Sandra, Dimitrijevic Sasa, Fletcher Jonathan A

Abstract excerpt

PURPOSE: Most gastrointestinal stromal tumors (GISTs) express constitutively activated mutant isoforms of KIT or kinase platelet-derived growth factor receptor alpha (PDGFRA) that are potential therapeutic targets for imatinib mesylate. The relationship between mutations in these kinases and clinical response to imatinib was examined in a group of patients with advanced GIST. PATIENTS AND METHODS: GISTs from 127...

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Identifiers

PMID: 14645423
DOI: 10.1200/JCO.2003.04.190

Genes

KIT
PDGFRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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