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Article

Expression of cyclin E renders cyclin D-CDK4 dispensable for inactivation of the retinoblastoma tumor suppressor protein, activation of E2F, and G1-S phase progression.

The Journal of biological chemistry - 13 Feb 2004

Keenan Susan M, Lents Nathan H, Baldassare Joseph J

Abstract excerpt

The activation of CDK2-cyclin E in late G1 phase has been shown to play a critical role in retinoblastoma protein (pRb) inactivation and G1-S phase progression of the cell cycle. The phosphatidylinositol 3-OH-kinase inhibitor LY294002 has been shown to block cyclin D1 accumulation, CDK4 activity and, thus, G1 progression in alpha-thrombin-stimulated IIC9 cells (Chinese hamster embryonic fibroblasts). Our previous...

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Source

Identifiers

PMID: 14645251
DOI: 10.1074/jbc.M310383200

Genes

CDK2
CDK4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expression of cyclin E renders cyclin D-CDK4 dispensable for inactivation of the retinoblastoma tumor suppressor protein, activation of E2F, and G1-S phase progression.PMID 14645251Read ↗

CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S PhaseSemantic proximity Read ↗

Reverse mutational analysis reveals threonine-373 as a potentially sufficient phosphorylation site for inactivation of the retinoblastoma tumor suppressor protein (pRB).Semantic proximity Read ↗

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Cyclin E-induced S phase without activation of the pRb/E2F pathway.Semantic proximity Read ↗

Interchangeable Roles for E2F Transcriptional Repression by the Retinoblastoma Protein and p27KIP1-Cyclin-Dependent Kinase Regulation in Cell Cycle Control and Tumor Suppression.Semantic proximity Read ↗

Multiple functions of D-type cyclins can antagonize pRb-mediated suppression of proliferation.Semantic proximity Read ↗

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