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Transcriptional repression of plasma cell differentiation is orchestrated by aberrant over-expression of the ETS factor<i>SPIB</i>in Waldenström macroglobulinaemia

7 May 2014

Abstract excerpt

In Waldenström macroglobulinaemia (WM), the mechanism(s) responsible for repression of B-cell differentiation remains unknown. We found that expression of SPIB and ID2 were significantly increased and decreased, respectively, in WM lymphoplasmacytic cells (LPC). Ectopic expression of SPIB in healthy donor CD19(+) cells inhibited plasmacytic differentiation in conjunction with decreased transcription of IRF4 and...

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PMID: 24801987
DOI: 10.1111/bjh.12936

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