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An Ikaros-Containing Chromatin-Remodeling Complex in Adult-Type Erythroid Cells

15 Oct 2000

Abstract excerpt

We have previously described a SWI/SNF-related protein complex (PYR complex) that is restricted to definitive (adult-type) hematopoietic cells and that specifically binds DNA sequences containing long stretches of pyrimidines. Deletion of an intergenic DNA-binding site for this complex from a human beta-globin locus construct results in delayed human gamma- to beta-globin switching in transgenic mice, suggesting...

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PMID: 11003653
DOI: 10.1128/mcb.20.20.7572-7582.2000

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