Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant presenilin (A260V) affects Rab8 in PC12D cell.

Neurochemistry international - 1 Apr 2004

Kametani Fuyuki, Usami Mihoko, Tanaka Kikuko, Kume Hideaki, Mori Hiroshi

Abstract excerpt

Most familial early-onset Alzheimer's disease (FAD) is caused by mutations in the presenilin-1 (PS1) gene. Abeta is derived from amyloid precursor protein (APP) and an increased concentration of Abeta 42 is widely believed to be a pathological hallmark of abnormal PS function. Therefore, the inte...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport, Active
Share to Contrast Media
Share to Neurites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PC12 Cells

Share to Presenilin-1

Share to rab GTP-Binding Proteins

Share to Subcellular Fractions

Share to trans-Golgi Network

Source

Identifiers

PMID: 14643748
DOI: 10.1016/s0197-0186(03)00176-1

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-14643748-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant presenilin (A260V) affects Rab8 in PC12D cell.PMID 14643748Read ↗

Human wild presenilin-1 mimics the effect of the mutant presenilin-1 on the processing of Alzheimer's amyloid precursor protein in PC12D cells.Semantic proximity Read ↗

Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.Semantic proximity Read ↗

Susceptibility to cellular stress in PS1 mutant N2a cells is associated with mitochondrial defects and altered calcium homeostasis.Semantic proximity Read ↗

Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transportSemantic proximity Read ↗

Presenilin-1 mutation alters NGF-induced neurite outgrowth, calcium homeostasis, and transcription factor (AP-1) activation in PC12 cells.Semantic proximity Read ↗

Mutant presenilin 1 increases the levels of Alzheimer amyloid beta-peptide Abeta42 in late compartments of the constitutive secretory pathway.Semantic proximity Read ↗

[Biochemistry of presenilin 1].Semantic proximity Read ↗

Chinese Presenilin-1 V97L mutation enhanced Abeta42 levels in SH-SY5Y neuroblastoma cells.Semantic proximity Read ↗

Abnormal cross-talk between mutant presenilin 1 (I143T, G384A) and glycosphingolipid biosynthesis.Semantic proximity Read ↗

[Study on expression of PS1 in APP-PS1 double gene stably transfected cell lines and its relation to gamma-secretase].Semantic proximity Read ↗

Enhanced generation of intracellular Abeta42 amyloid peptide by mutation of presenilins PS1 and PS2.Semantic proximity Read ↗

Presenilin-1 mutations associated with familial Alzheimer's disease do not disrupt protein transport from the endoplasmic reticulum to the Golgi apparatus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.