Article
Presenilin-1 mutations associated with familial Alzheimer's disease do not disrupt protein transport from the endoplasmic reticulum to the Golgi apparatus.
Biochimica et biophysica acta - 1 Jul 1998
Tan Y, Hong J, Doan T, McConlogue L, Maltese W A
Abstract excerpt
Mutations in genes encoding presenilin-1 (PS1) and presenilin-2 (PS2) have been linked to familial forms of Alzheimer's disease (AD). Cells expressing mutant presenilins produce elevated levels of Abeta42, the major amyloid peptide found in AD plaques. The mechanism whereby this occurs remains un...
Topics
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Biological Transport
- Endoplasmic Reticulum
- Golgi Apparatus
- Humans
- Membrane Proteins
- Mutation
- Peptide Fragments
- Presenilin-1
- Protein Processing, Post-Translational
- Receptors, LDL
- Sweden