Article
Lack of association between TrkA single nucleotide polymorphisms and sporadic Alzheimer's disease in a Japanese population.
Neuroscience letters - 15 Dec 2003
Sakasegawa Yuji, Kishida Hitaru, Sakurai Michiko, Asada Takashi, Kinoshita Toru, Goto Yuichi, Kimura Hideo, Kuroiwa Yoshiyuki, Hachiya Naomi S, Kaneko Kiyotoshi
Abstract excerpt
Nerve growth factor and its receptor with tyrosine kinase activity (TrkA) have been implicated in the development of Alzheimer's disease (AD). Entire coding regions of TrkA gene harboring exons 1 through 17 were sequenced in 114 patients with sporadic AD and 112 control subjects in a Japanese population, and six known and two novel single nucleotide polymorphisms were identified, but no mutation associated with...
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