Maternal effect: an additional mechanism maintaining balanced polymorphisms of haemoglobinopathies?

doi:10.1046/j.1529-8817.2003.00068.x

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Article

Maternal effect: an additional mechanism maintaining balanced polymorphisms of haemoglobinopathies?

Annals of human genetics - 1 Nov 2003

Duchovni-Silva I, Ramalho A S

Abstract excerpt

The malarial hypothesis presupposes that carriers of sickle cell trait and beta-thalassaemia are born in accordance with Mendelian inheritance and later favoured by an environmental factor. However, an eventual distortion favouring the transmission of the mutant allele is also a plausible hypothesis. The Mendelian proportion was tested in the progeny of 201 sickle cell trait (AS) and 138 beta-thalassaemia (AT)...

Topics

Adult
Alleles
Anemia, Sickle Cell
Brazil
Female
Genetics, Population
Humans
Infant Mortality
Infant, Newborn
Male
Mothers
Pedigree
Polymorphism, Genetic
beta-Thalassemia

Source

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Identifiers

PMID: 14641241
DOI: 10.1046/j.1529-8817.2003.00068.x

Provenance

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