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Article

Maternal effect: an additional mechanism maintaining balanced polymorphisms of haemoglobinopathies?

Annals of human genetics - 1 Nov 2003

Duchovni-Silva I, Ramalho A S

Abstract excerpt

The malarial hypothesis presupposes that carriers of sickle cell trait and beta-thalassaemia are born in accordance with Mendelian inheritance and later favoured by an environmental factor. However, an eventual distortion favouring the transmission of the mutant allele is also a plausible hypothesis. The Mendelian proportion was tested in the progeny of 201 sickle cell trait (AS) and 138 beta-thalassaemia (AT)...

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Identifiers

PMID: 14641241
DOI: 10.1046/j.1529-8817.2003.00068.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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