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Article

NF-kappaB activity blockade impairs the angiogenic potential of human pancreatic cancer cells.

International journal of cancer - 10 Jan 2004

Xiong Henry Q, Abbruzzese James L, Lin Edward, Wang Liwei, Zheng Leizhen, Xie Keping

Abstract excerpt

The effect of blockade of NF-kappaB activity on human pancreatic cancer angiogenesis was determined in an orthotopic xenograft model. Highly metastatic L3.3 human pancreatic cancer cells, which expressed an elevated level of constitutive NF-kappaB activity, were transfected with a mutated IkappaBalpha (IkappaBalphaM). After implantation in the pancreas of nude mice, parental (L3.3) and control vector-transfected...

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Identifiers

PMID: 14639600
DOI: 10.1002/ijc.11562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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