Article
Function of nuclear factor kappaB in pancreatic cancer metastasis.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2003
Fujioka Shuichi, Sclabas Guido M, Schmidt Christian, Frederick Wayne A, Dong Qiang G, Abbruzzese James L, Evans Douglas B, Baker Cheryl, Chiao Paul J
Abstract excerpt
PURPOSE: We seek to elucidate the role of constitutive nuclear factor kappaB (NFkappaB) activity in human pancreatic cancer cells. We have demonstrated that the transcription factor NFkappaB is activated constitutively in human pancreatic adenocarcinoma and human pancreatic cancer cell lines but not in normal pancreatic tissues or in immortalized/nontumorigenic pancreatic epithelial cells, suggesting that...
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